团队介绍：

2011-2013年在北京大学泌尿外科研究所在站博士后研究，后留所工作至今，主要从事泌尿良性疾病，如上尿路损伤后纤维化、男性性功能障碍的分子机制及干预研究方面的工作。在包括Advanced Science、 Andrology、World Journal of Mens Health 等著名期刊上发表SCI论文30余篇；近5年承担国家自然科学基金面上项目2项；获华夏医学科技三等奖一项（排名第二）；已授权国家发明专利一项（排名第一）。现任中国医促会泌尿男性生殖医学分会委员。

项目情况：

在研项目：

1. NFATC3/YAP/SMAD转录复合体介导的Engrailed-1表达在输尿管狭窄纤维化中的作用机制研究，国自然面上基金，202601-2029.12

2. 国家自然科学基金委员会, 面上项目, 扁柏双黄酮联合淫羊藿次苷II激活eNOS/NO信号通路改善大鼠勃起功能障碍的作用机制研究, 2023-01-01 至 2026-12-31

招生信息（拟招生的研究方向）：

1. 上尿路器官纤维化的发病机制及干预研究

2. 男性勃起功能障碍的分子发病机制

科研项目：

近五年主持科研项目课题：

1. 国家自然科学基金委员会, 面上项目，NFATC3/YAP/SMAD转录复合体介导的Engrailed-1表达在输尿管狭窄纤维化中的作用机制研究，202601-2029.12

2. 国家自然科学基金委员会，面上项目，扁柏双黄酮联合淫羊藿次苷II激活eNOS/NO信号通路改善大鼠勃起功能障碍的作用机制研究，2023-01-01 至 2026-12-31

3. 国家自然科学基金委员会，面上项目，淫羊藿次苷II调控MAPK信号通路激活阴茎原位内皮祖细胞的机制研究，2020-01-01 至 2023-12-31

代表性研究成果：

近5年发表文章：

[1] Xiaohui Tan*, Kefan Li*, Yiming Yuan#, Mancheng Xia, Fangzhou Zhao, Honggang Ying, Zhuo Zhou, Pengchao Gao, Guoqing Xie, Xuesong Li#, Hui Jiang#, Ruili Guan#. Palmitoylation-mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High-Fat-Induced Erectile Dysfunction [J]. Advanced Science(Weinh). 2026 Jan 29:e13796

[2] Pengchao Gao*, Xiaohui Tan*, Mancheng Xia, Kefan Li, Fangzhou Zhao, Honggang Ying, Zhuo Zhou, Yiming Yuan, Tiegui Nan#, Ruili Guan#. Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway [J]. Sexual Medicine, 2025, 13(4): qfaf059.

[3] Mancheng Xia*, Yiming Yuan*, Dong Fang, Xiaohui Tan, Fangzhou Zhao, Xinfei Li, Pengchao Gao, Zhuo Zhou, Tiegui Nan, Zhongcheng Xin, Xuesong Li#, Ruili Guan#. Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway [J]. The World Journal of Men's Health, 2025, 43(3): 580-594.

[4] Xiaohui Tan, Yangyang Gu, Wenpeng Song, Tiegui Nan, Weidong Song, Dong Fang, Yiming Yuan, Zhongcheng Xin, Xuesong Li#, Ruili Guan#. Transcriptome analysis highlights the role of ferroptosis in palmitic acid – induced endothelial dysfunction [J]. Sexual Medicine, 2023, 11(1): qfac008.

[5] Wenpeng Song*, Yiming Yuan*, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang#, Ruili Guan#. Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways [J]. PeerJ, 2022, 10: e14192.

[6] Wenpeng Song*, Shengji Gu*, Xiaohui Tan, Yangyang Gu, Weidong Song, Jianyu Zeng, Zhongcheng Xin, Ruili Guan#. Proteomic analysis and miRNA profiling of human testicular endothelial cell-derived exosomes: the potential effects on spermatogenesis [J]. Asian Journal of Andrology, 2022, 24(5): 478-486.

[7] Yangyang Gu*, Xiaohui Tan*, Wenpeng Song, Weidong Song, Yiming Yuan, Zhongcheng Xin, Jiadong Wang#, Dong Fang#, Ruili Guan#. Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway [J]. Frontiers in Pharmacology, 2022, 13: 920601.

[8] Xiaohui Tan, Shengji Gu, Wenjie Tian, Wenpeng Song, Yangyang Gu, Yiming Yuan, Xuesong Li, Zhongcheng Xin, Sae Woong Kim, Ruili Guan#, Woong Jin Bae#. Extracellular vesicles derived from human Sertoli cells: characterizations, proteomic analysis, and miRNA profiling [J]. Molecular Biology Reports, 2022, 49(6): 4673-4681.

[9] Dong Fang*, Xiaohui Tan*, Wenpeng Song, Yangyang Gu, Jiancheng Pan, Xiaoqing Yang, Weidong Song, Yiming Yuan, Jing Peng, Zhichao Zhang, Zhongcheng Xin, Xuesong Li#, Ruili Guan#. Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction [J]. Frontiers in Endocrinology, 2022, 13: 874915.

[10] Shengji Gu, Meng Li, Yiming Yuan, Zhongcheng Xin#, Ruili Guan#. A novel

flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury [J]. Andrology, 2021, 9(6): 1893-1901.

[11] Xiaohui Tan*, Dong Fang*, Yongde Xu*, Tiegui Nan, Wenpeng Song, Yangyang Gu, Shengji Gu, Yiming Yuan, Zhongcheng Xin, Liqun Zhou, Ruili Guan#, Xuesong Li#. Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “ Salting-Out ” : Characterizations and Potential Functions as Nanocarriers [J]. Frontiers in Nutrition, 2021, 8: 769223.

[12] Wanshou Cui*, Ruili Guan*, Hongen Lei, Jihong Liu, Tao Wang, Sainan Zhu, Chen Yao, Jiang Wang, Yuhong Feng, Long Tian#, Zhongcheng Xin#. Efficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial [J]. Translational Andrology and Urology, 2021, 10(8): 3358-3367. 

获奖情况：

淫羊藿苷及淫羊藿次苷Ⅱ防治勃起功能障碍的药理药效及作用机理，华夏医学科技奖，三等奖, 2018.11，辛钟成、关瑞礼、李辉喜、袁亦铭 

发明专利：

一种从牛奶中提取细胞外囊泡的方法，20220614，关瑞礼、谭晓辉、方冬、李学松、周利群